Landmark Deal Brings Affordable HIV Protection Jab to Millions

A breakthrough agreement slashes cost of life-saving Lenacapavir injection, boosting hopes of ending the global HIV epidemic

A groundbreaking agreement promises to make the revolutionary HIV prevention drug, Lenacapavir, widely available at an affordable price in over 120 low- and middle-income countries. Within the next two years, millions of people could gain access to this long-acting injectable, which has been hailed as one of the most promising tools in the fight against HIV and AIDS.

From $28,000 to $40 a Year

Currently priced at a staggering $28,000 per person annually, Lenacapavir has remained out of reach for most people in low-income regions. But under this new deal, the cost will be reduced to just $40 per person per year—a remarkable 0.1% of the original price. Distribution of the low-cost version is set to begin in 2027, offering hope to populations most at risk.

Clinton Foundation Leads Negotiations

The deal was secured through the efforts of former US President Bill Clinton, working alongside the Clinton Foundation, the Gates Foundation, and South Africa’s Wits RHI research institute. This coalition of partners played a pivotal role in negotiating with pharmaceutical companies to ensure affordability and accessibility for developing nations.

How Lenacapavir Works

Lenacapavir functions by stopping the HIV virus from replicating inside human cells. Unlike traditional pre-exposure prophylaxis (PrEP) pills that require daily use, Lenacapavir is injected just twice a year, providing six months of continuous protection. Its simplicity and effectiveness make it a game-changer for communities facing difficulties with daily medication adherence.

Backing from the World Health Organization

In July, the World Health Organization (WHO) officially endorsed Lenacapavir for HIV prevention following impressive trial results. One notable study reported a 100% success rate, highlighting the drug’s potential as both a preventive and therapeutic tool. Regulatory approval is still pending for the generic version, but scientists hope it will be cleared within the next 18 months.

A Lifeline for Vulnerable Groups

Experts stress that long-acting injectables could significantly reduce infection rates in vulnerable groups such as adolescent girls, young women, sex workers, LGBT communities, and people who use drugs. These populations often face higher risks of exposure and barriers to consistent treatment. The new injection could overcome those challenges by providing a discreet and reliable method of protection.

Replacing the Limitations of PrEP

PrEP, the widely used oral preventive drug, costs about the same $40 annually but its effectiveness is hindered by stigma and the burden of daily consumption. According to the Gates Foundation, only 18% of those who could benefit from PrEP currently have access. Lenacapavir’s twice-yearly injections could significantly improve compliance and uptake, closing the gap in HIV prevention.

Global HIV Burden Remains High

Despite decades of progress, UNAIDS estimates over 40 million people live with HIV worldwide. In 2024 alone, about 1.3 million new infections were reported, and more than 600,000 people died from AIDS-related illnesses. South Africa, home to nearly eight million HIV-positive individuals, will be among the first to receive the new, affordable injection.

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Preventing Millions of Infections

Modeling studies suggest that making Lenacapavir accessible to just 4% of the population could cut 20% of new infections globally. Beyond prevention, researchers note that the drug also has potential for treating existing HIV cases, offering dual benefits in both reducing transmission and improving care.

A Step Toward Ending the Epidemic

This announcement arrives during a challenging period for global health, particularly after foreign aid cuts by the US government. Nevertheless, the rollout of affordable Lenacapavir is being hailed as a landmark achievement that could finally put the world on a faster track toward ending the HIV epidemic.

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